ARHGAP17 and TRIP10

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		ARHGAP17	TRIP10
Description		Rho GTPase activating protein 17	thyroid hormone receptor interactor 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RAC3 GTPase cycle	Clathrin-mediated endocytosis RHOQ GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		16 interacting genes: ABL1 APP BTK CDC42 CRK CTTN DNMBP FNBP1 GRB2 LCK PACSIN1 PIK3R1 RAC1 SH3GLB1 SRC TRIP10	43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B
Entrez ID		55114	9322
HPRD ID		12207	05142
Ensembl ID		ENSG00000140750	ENSG00000125733
Uniprot IDs		Q68EM7	Q15642 W4VSQ9
PDB IDs			2CT4 2EFK 2KE4
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Endocytosis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Phosphotyrosine Residue Binding Import Into Cell Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Endocytosis Positive Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cell-cell Junction Positive Regulation Of Locomotion Regulation Of Actin Filament-based Process Positive Regulation Of Lamellipodium Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell-substrate Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade SH2 Domain Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Regulation Of Actin Filament Organization Phospholipase Activator Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization B Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Cell Adhesion Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Signal Transduction Regulation Of Organelle Organization Regulation Of Vesicle-mediated Transport Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Cell Motility	Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette
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