IFT57 and CBLB

		IFT57	CBLB
Description		intraflagellar transport 57	Cbl proto-oncogene B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Cilium Axoneme Intraciliary Transport Particle B Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Dendrite Terminus Ciliary Tip Ciliary Base	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft Postsynapse Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Neural Tube Closure Heart Looping Apoptotic Process Smoothened Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Intraciliary Anterograde Transport Intraciliary Transport Regulation Of Apoptotic Process Keratinocyte Proliferation Motile Cilium Assembly Cilium Assembly Left/right Pattern Formation Non-motile Cilium Assembly	Positive Regulation Of T Cell Anergy T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of Protein Catabolic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 31043756) Regular attendance at a religious group ( 29970889)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840 28445677 31604244) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		8 interacting genes: EXOC5 HIP1 IFT20 SKA2 UBXN10 WASHC1 YAF2 ZDHHC17	53 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 OSTF1 PIK3R1 PLCG2 PRMT2 PTK6 RET RNF11 SH3KBP1 SH3RF1 SHC1 SORBS2 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 VAV3 VPS26C YES1 ZAP70
Entrez ID		55081	868
HPRD ID		09430	05136
Ensembl ID		ENSG00000114446	ENSG00000114423
Uniprot IDs		Q9NWB7	B3KSS7 B4DYP3 B7ZAG1 Q13191
PDB IDs			2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI 8GCY 8QNG 8QNH 8QNI 8QTG 8QTH 8QTJ 8QTK 8VW4 8VW5 9FQH 9FQI 9FQJ
Enriched GO Terms of Interacting Partners?		Protein Transport Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Intracellular Protein Localization Cytoplasmic Vesicle Exocyst Cellular Localization Establishment Of Localization In Cell Intraciliary Transport Particle B Clathrin Coat Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Establishment Of Planar Polarity Organelle Assembly Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Intracellular Transport Centriole Cytoplasmic Vesicle Membrane Positive Regulation Of Cilium Assembly Cytoskeleton Regulation Of Cell Projection Assembly Establishment Of Spindle Orientation Phosphate:proton Symporter Activity Mitochondrial Phosphate Ion Transmembrane Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Perforant Pathway To Dendrate Granule Cell Synapse Establishment Of Spindle Localization Spindle Localization Cilium Assembly Cellular Component Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Presynaptic Endocytic Zone Membrane Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Cilium Organization Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Opsin Transport Intraciliary Transport Particle Regulation Of Receptor Internalization Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Vesicle Autophagosome	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell Motility Positive Regulation Of Cell Communication Cytoplasm Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Intracellular Signaling Cassette Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Leukocyte Migration Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Lymphocyte Activation Lamellipodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lamellipodium Organization Regulation Of Cell Activation Fc-epsilon Receptor Signaling Pathway Leukocyte Activation Immune System Process Cytosol T Cell Activation Positive Regulation Of Cell Activation
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