TMEM45A and ERMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM45A	ERMP1
Description		transmembrane protein 45A	endoplasmic reticulum metallopeptidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process		Proteolysis Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress
Pathways
Drugs
Diseases
GWAS		Fasting glucose ( 34059833) Refractive error ( 32231278) Skin aging (microtopography measurement) ( 28502801)	Asthma ( 31619474 31959851) Blond vs. brown/black hair color ( 30531825) Waist-hip ratio ( 28552196)
Interacting Genes		9 interacting genes: APOA2 ARLN ERMP1 GJA8 IGFBP5 PLN SSMEM1 TMEM19 TRARG1	39 interacting genes: AQP2 AQP6 ATP1B4 BCL2L13 BSCL2 CD200R1 CLDN5 CLDN7 CLDN9 CLEC2D CREB3L1 ERVFRD-1 FAM209A FKBP7 FNDC9 GJA8 GPR42 GPRC5D HHLA2 HIBADH IER3IP1 IFNGR2 KCNN3 KLRC1 LYPD5 MR1 PDCD1LG2 PEX12 RHCG SLC13A4 SLC18A1 SLC22A23 SLC23A2 SLC7A14 SPAG4 SSMEM1 TMEM237 TMEM45A TMEM80
Entrez ID		55076	79956
HPRD ID		07647	17227
Ensembl ID		ENSG00000181458	ENSG00000099219
Uniprot IDs		J3KQ06 Q9NWC5	A0A8I5KNY4 A0A8I5KXJ0 E7ER77 Q6ZMD3 Q7Z2K6
PDB IDs		7OQZ
Enriched GO Terms of Interacting Partners?		Regulation Of System Process Negative Regulation Of Muscle Hypertrophy Response To Peptide Hormone Regulation Of Muscle System Process Negative Regulation Of Skeletal Muscle Hypertrophy Response To Hormone Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Negative Regulation Of Cholesterol Import Insulin-like Growth Factor Binding Protein Complex Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Diacylglycerol Catabolic Process Regulation Of Cholesterol Import Lipase Inhibitor Activity Apolipoprotein Receptor Binding Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Gap Junction-mediated Intercellular Transport Mammary Gland Involution Insulin-like Growth Factor Ternary Complex Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Transporter Inhibitor Activity Regulation Of Cardiac Muscle Cell Membrane Potential Circadian Sleep/wake Cycle Process ATPase Inhibitor Activity Regulation Of Relaxation Of Cardiac Muscle Sleep Response To Insulin Response To Thyroxine TOM Complex Mitochondrion Targeting Sequence Binding Response To L-phenylalanine Derivative Glucose Import In Response To Insulin Stimulus	Membrane Transmembrane Transport Plasma Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Transmembrane Transporter Activity Protein Binding Renal Water Transport Bicellular Tight Junction Assembly External Side Of Plasma Membrane Ammonium Channel Activity Ammonium Transmembrane Transport Tight Junction Assembly Nuclear Inner Membrane Tight Junction Organization Amine Transport Water Channel Activity Carbon Dioxide Transport Structural Molecule Activity
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