NRDE2 and VPS28

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NRDE2	VPS28
Description		NRDE-2, necessary for RNA interference, domain containing	VPS28 subunit of ESCRT-I
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Mitotic Cell Cycle MRNA Processing DNA Damage Response RNA Splicing Regulatory NcRNA-mediated Heterochromatin Formation Positive Regulation Of RNA Export From Nucleus MRNA Stabilization Cell Division Negative Regulation Of RNA Catabolic Process	Protein Transport Macroautophagy Negative Regulation Of Protein Ubiquitination Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Membrane Fission Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways			Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Lifespan ( 25918517) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988)
Interacting Genes		11 interacting genes: ARFIP2 CCDC183 HAUS8 ITGB3BP LHX3 MED29 MESD RCOR3 SPG21 UQCC2 VPS28	48 interacting genes: ABI2 AKTIP ASF1A BEX2 BLZF1 CARD9 CBX5 CCDC146 CDK18 CEP57L1 CFTR COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SNCA SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52
Entrez ID		55051	51160
HPRD ID		12625	11675
Ensembl ID		ENSG00000119720	ENSG00000160948
Uniprot IDs		Q9H7Z3	A0A0S2Z5H5 Q548N1 Q9UK41
PDB IDs		6IEH	6VME
Enriched GO Terms of Interacting Partners?			Viral Budding Via Host ESCRT Complex Viral Budding ESCRT I Complex Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Membrane Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagy Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Protein Localization To Vacuole Protein Binding Vacuolar Transport Endosomal Transport Membrane Fission Multivesicular Body Sorting Pathway Cytoplasm Identical Protein Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization To Vacuole Nucleus Viral Process Calcium-dependent Protein Binding Microtubule Binding Positive Regulation Of Exocytosis AMP-activated Protein Kinase Activity Regulation Of Extracellular Exosome Assembly Protein Transport Vesicle Organization Protein Kinase Inhibitor Activity Protein Targeting Regulation Of Protein Modification Process Nucleotide-activated Protein Kinase Complex SMN Complex Protein Targeting To Vacuole Protein-containing Complex Binding Gemini Of Cajal Bodies Positive Regulation Of Actin Nucleation Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Protein Tag Activity Organelle Assembly Establishment Of Localization In Cell Intracellular Protein Localization SMN-Sm Protein Complex
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