AURKAIP1 and AJUBA

Number of citations of the paper that reports this interaction (PubMedID 13678582)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		AURKAIP1	AJUBA
Description		aurora kinase A interacting protein 1	ajuba LIM protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	P-body Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Membrane Lamellipodium Anchoring Junction
	Molecular Function	Protein Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Kinase Activator Activity Alpha-catenin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Mitochondrial Translation Positive Regulation Of Proteolysis	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of DNA-templated Transcription Cytoskeleton Organization Cell Adhesion Intracellular Protein Localization Positive Regulation Of Biosynthetic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Protein-containing Complex Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of PLK1 Activity at G2/M Transition Activation of anterior HOX genes in hindbrain development during early embryogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Ulcerative colitis ( 28067908)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Insular cortex volume ( 31530798) Macular thickness ( 30535121) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Spatial processing ( 31596458)
Interacting Genes		6 interacting genes: ABHD4 AJUBA AURKA DEFB127 FAM9B GSK3A	24 interacting genes: ACTA1 AURKA AURKAIP1 AURKB BCAR1 CATSPER1 CREB5 CTNNA1 FARS2 GFI1B GRB2 ITSN1 LATS2 LCK LGALS14 PIN1 RPA1 SLC1A2 TEKT3 TFAP4 TSG101 WEE2-AS1 ZNF512B ZNF541
Entrez ID		54998	84962
HPRD ID		16457	16426
Ensembl ID		ENSG00000175756	ENSG00000129474
Uniprot IDs		Q9NWT8	Q96IF1
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of UDP-glucose Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Mitochondrion Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Meiotic Cell Cycle Positive Regulation Of Proteolysis Autosome Genomic Imprinting Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity Spindle Assembly Involved In Female Meiosis I Pronucleus Germinal Vesicle Chromosome Passenger Complex Mitotic Centrosome Separation Histone H3S10 Kinase Activity Axon Hillock Positive Regulation Of Oocyte Maturation Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Cell Maturation N-acylphosphatidylethanolamine Metabolic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Glycerophospholipid Metabolic Process Regulation Of Microtubule-based Process Phosphatidylethanolamine Acyl-chain Remodeling Alpha-catenin Binding Cardiac Left Ventricle Morphogenesis Cilium Disassembly Lysophosphatidic Acid Acyltransferase Activity Beta-catenin Destruction Complex Centrosome Separation Spindle Assembly Involved In Female Meiosis	B Cell Receptor Signaling Pathway Chromosome Passenger Complex Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Lamellipodium Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cytokinesis Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Meiotic Cell Cycle Spindle Midzone Negative Regulation Of Protein Phosphorylation Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Phosphorylation Protein Serine/threonine/tyrosine Kinase Activity Nucleus Regulation Of Protein Localization To Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Nuclear Division Cis-trans Isomerase Activity Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Phase Transition Spindle Pole Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Brood Size Outer Acrosomal Membrane Spindle Microtubule Negative Regulation Of Phosphate Metabolic Process T Cell Costimulation Centrosome Regulation Of Cell Division Regulation Of Protein Phosphorylation
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