AURKAIP1 and DEFB127

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AURKAIP1	DEFB127
Description		aurora kinase A interacting protein 1	defensin beta 127
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Extracellular Region
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitochondrial Translation Positive Regulation Of Proteolysis	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Beta defensins Defensins
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Ulcerative colitis ( 28067908)	Coronary artery disease in type 1 diabetes ( 32077919)
Interacting Genes		6 interacting genes: ABHD4 AJUBA AURKA DEFB127 FAM9B GSK3A	14 interacting genes: AQP6 ASZ1 AURKAIP1 BCL2L13 CD79A CPLX4 EBP FAM174A FCER1G LMNA MMGT1 PIANP SLC71A2 TFEC
Entrez ID		54998	140850
HPRD ID		16457	10877
Ensembl ID		ENSG00000175756	ENSG00000088782
Uniprot IDs		Q9NWT8	Q9H1M4
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of UDP-glucose Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Mitochondrion Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Meiotic Cell Cycle Positive Regulation Of Proteolysis Autosome Genomic Imprinting Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity Spindle Assembly Involved In Female Meiosis I Pronucleus Germinal Vesicle Chromosome Passenger Complex Mitotic Centrosome Separation Histone H3S10 Kinase Activity Axon Hillock Positive Regulation Of Oocyte Maturation Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Cell Maturation N-acylphosphatidylethanolamine Metabolic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Glycerophospholipid Metabolic Process Regulation Of Microtubule-based Process Phosphatidylethanolamine Acyl-chain Remodeling Alpha-catenin Binding Cardiac Left Ventricle Morphogenesis Cilium Disassembly Lysophosphatidic Acid Acyltransferase Activity Beta-catenin Destruction Complex Centrosome Separation Spindle Assembly Involved In Female Meiosis
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