CLN6 and EVI2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLN6	EVI2B
Description		CLN6 transmembrane ER protein	ecotropic viral integration site 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Membrane Raft	Plasma Membrane Membrane
	Molecular Function	Protein Binding Lysophosphatidic Acid Binding Protein Homodimerization Activity Sulfatide Binding	Protein Binding
	Biological Process	Ganglioside Metabolic Process Lysosome Organization Lysosomal Lumen Acidification Visual Perception Cholesterol Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Glycosaminoglycan Metabolic Process Locomotion Involved In Locomotory Behavior Positive Regulation Of Proteolysis	Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Neutrophil Differentiation Regulation Of Cell Cycle Myeloid Cell Development Regulation Of Stem Cell Division
Pathways
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Major depressive disorder ( 23377640) Restless legs syndrome ( 29029846)	Brain morphology (MOSTest) ( 32665545) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		26 interacting genes: ARL13B CD79A CISD2 CLDN7 CLEC10A CPLX4 CREB3L1 CYBC1 EBAG9 EVI2B FAM209A FNDC9 GJA8 GORAB KIR2DL3 LIME1 LMNA LRRC25 RIC3 SLC22A23 SLC30A4 STX1A TEX264 TMEM139 TMEM237 TMPRSS2	31 interacting genes: APOD AQP1 AQP3 BTN2A2 CDIPT CLN6 CNIH1 DESI1 DRAM1 FAM3C FUNDC2 GALNT15 GIMAP5 MYADML2 NINJ2 NSG1 PGRMC1 RTP2 SCAMP4 SLC2A5 SLC30A2 SLC38A7 SLC39A9 TMEM107 TMEM222 TMEM60 TMEM86B TRAF3IP3 TRAM1L1 UBIAD1 VAMP4
Entrez ID		54982	2124
HPRD ID		05991	08867
Ensembl ID		ENSG00000128973	ENSG00000185862
Uniprot IDs		A0A024R601 Q9NWW5	P34910 Q9BRW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex	Membrane Polyol Transmembrane Transport Renal Water Transport Renal Water Absorption Glycerol Transmembrane Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Lysosome Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Water Channel Activity Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Protein Binding Renal Water Homeostasis Lysosomal Membrane Establishment Of Protein Localization To Membrane Golgi Apparatus Endoplasmic Reticulum Negative Regulation Of Lipoprotein Lipid Oxidation Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Multicellular Organismal-level Water Homeostasis One-carbon Compound Transport Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Water Transport Fructose Import Across Plasma Membrane Zinc Ion Import Into Zymogen Granule Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Trans-Golgi Network Membrane CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Multivesicular Body Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity D-lysine 5,6-aminomutase Activity
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