CLN6 and SLC30A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLN6	SLC30A4
Description		CLN6 transmembrane ER protein	solute carrier family 30 member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Membrane Raft	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane
	Molecular Function	Protein Binding Lysophosphatidic Acid Binding Protein Homodimerization Activity Sulfatide Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Metal Ion Binding
	Biological Process	Ganglioside Metabolic Process Lysosome Organization Lysosomal Lumen Acidification Visual Perception Cholesterol Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Glycosaminoglycan Metabolic Process Locomotion Involved In Locomotory Behavior Positive Regulation Of Proteolysis	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Response To Toxic Substance Response To Zinc Ion Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Export Across Plasma Membrane Zinc Ion Import Into Lysosome
Pathways
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Major depressive disorder ( 23377640) Restless legs syndrome ( 29029846)	Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		26 interacting genes: ARL13B CD79A CISD2 CLDN7 CLEC10A CPLX4 CREB3L1 CYBC1 EBAG9 EVI2B FAM209A FNDC9 GJA8 GORAB KIR2DL3 LIME1 LMNA LRRC25 RIC3 SLC22A23 SLC30A4 STX1A TEX264 TMEM139 TMEM237 TMPRSS2	14 interacting genes: BTN2A2 CLN6 CMTM5 FZD7 IER3IP1 LEPROTL1 NSG1 PEDS1-UBE2V1 SERP2 TMEM100 TMEM60 TNF TNFRSF10C YIPF6
Entrez ID		54982	7782
HPRD ID		05991	03651
Ensembl ID		ENSG00000128973	ENSG00000104154
Uniprot IDs		A0A024R601 Q9NWW5	O14863
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex
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