NMRK1 and INCA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NMRK1	INCA1
Description		nicotinamide riboside kinase 1	inhibitor of CDK, cyclin A1 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Nicotinate Riboside Kinase Activity Metal Ion Binding Ribosylnicotinamide Kinase Activity Ribosylnicotinate Kinase Activity	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	NADP+ Biosynthetic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process NAD+ Biosynthetic Process Via The Salvage Pathway	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Nicotinate metabolism
Drugs
Diseases
GWAS		Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Urinary magnesium-to-creatinine ratio ( 29093028)	Intraocular pressure ( 29235454) Keratoconus ( 33649486) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: APP INCA1 KCTD21 REL TAX1BP1	236 interacting genes: ABI2 ACTMAP ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13B EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SAXO4 SCNM1 SEC14L4 SHFL SLC67A1-AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2
Entrez ID		54981	388324
HPRD ID		09868	17150
Ensembl ID		ENSG00000106733	ENSG00000196388
Uniprot IDs		B3KUG3 Q5W125 Q9NWW6	Q0VD86
PDB IDs		2P0E 2QG6 2QL6 2QSY 2QSZ 2QT0 2QT1
Enriched GO Terms of Interacting Partners?		Protein Homooligomerization Protein Complex Oligomerization Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Innate Immune Response Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Defense Response To Symbiont Regulation Of Response To Calcium Ion Regulation Of Signal Transduction Axon Midline Choice Point Recognition Defense Response To Other Organism Amylin Binding Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Signaling Identical Protein Binding Positive Regulation Of Protein Glycosylation NF-kappaB Complex Protein Localization To Phagocytic Vesicle Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Golgi Disassembly Axon Choice Point Recognition Regulation Of Protein Glycosylation Heparan Sulfate Binding Signaling Receptor Activator Activity	Protein Binding Intermediate Filament Cytosol COPII Vesicle Coating Spindle Pole Centrosome Cytoplasm Nucleus Identical Protein Binding Cyclin A1-CDK2 Complex MRNA Processing Vesicle Coating Positive Regulation Of Ubiquitin-dependent Endocytosis
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