PPM1G and GGCX

		PPM1G	GGCX
Description		protein phosphatase, Mg2+/Mn2+ dependent 1G	gamma-glutamyl carboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding	Gamma-glutamyl Carboxylase Activity Lyase Activity Vitamin Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Cell Cycle	Blood Coagulation Protein Modification Process Vitamin K Metabolic Process Negative Regulation Of Neurotransmitter Secretion Protein Maturation Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process
Pathways			Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs			IIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bone mineral density (total hip) ( 29883787) Creatinine levels ( 31015462) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Non-oily fish consumption ( 32066663) Takayasu arteritis ( 25604533) Triglyceride levels ( 31928498)	Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: FBXO38 GRIA3 H3-4 HEXIM1 LRPAP1 MSL1 MTNR1B RN7SK RPS6KA1 TERF1 TERF2	7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2
Entrez ID		5496	2677
HPRD ID		09237	00665
Ensembl ID		ENSG00000115241	ENSG00000115486
Uniprot IDs		O15355 Q6IAU5	A0A8I5QJA4 P38435
PDB IDs			9BUM 9BUR 9BUX 9BVK 9BVL 9BVM 9BVO 9BVP 9BVQ 9BVR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication 7SK SnRNP Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Transcription Elongation By RNA Polymerase II RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription, Elongation Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gamma-glutamyl Carboxylase Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Vitamin Binding Negative Regulation Of Bone Development Chemical Synaptic Transmission Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Trans-synaptic Signaling Synaptic Signaling Regulation Of DNA Biosynthetic Process Amyloid-beta Binding DNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Testosterone Biosynthetic Process Rough Endoplasmic Reticulum Lumen Negative Regulation Of T-circle Formation Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of DNA-templated Transcription Elongation	Golgi Lumen Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Serine-type Endopeptidase Activity Calcium Ion Binding Regulation Of Blood Coagulation Regulation Of Hemostasis Endopeptidase Activity Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Response To Vitamin K Response To Hydroxyisoflavone Regulation Of Response To Wounding Response To Phenylpropanoid Positive Regulation Of Wound Healing Peptidase Activity Extracellular Region Protein Metabolic Process Proteolysis Protein Processing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cytotoxic T Cell Differentiation Negative Regulation Of Coagulation Response To Astaxanthin Hydrolase Activity Response To Estrogen Golgi Cisterna Membrane Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Wound Healing Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Golgi Calcium Ion Transport Golgi Calcium Ion Homeostasis P-type Manganese Transporter Activity Trans-Golgi Network Membrane Organization Response To Vitamin Protein Maturation Positive Regulation Of TOR Signaling Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Iron Chaperone Activity Ferroxidase Activity
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