SARS2 and HLCS

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SARS2	HLCS
Description		seryl-tRNA synthetase 2, mitochondrial	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Serine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Seryl-tRNA Aminoacylation Mitochondrial Seryl-tRNA Aminoacylation	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways		Mitochondrial tRNA aminoacylation	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS			Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		7 interacting genes: CASP3 EEF1A1 ESR1 HLCS NTAQ1 OGT UBC	10 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15
Entrez ID		54938	3141
HPRD ID		15295	08360
Ensembl ID		ENSG00000104835	ENSG00000159267
Uniprot IDs		Q9NP81	A0A8C8QSB1 P50747
PDB IDs		7TZB 7U2A 7U2B 7YDF 7YDG 8FFY
Enriched GO Terms of Interacting Partners?		Protein Modification Process Ovulation Cycle Process Rhythmic Process Pyroptotic Inflammatory Response Macromolecule Metabolic Process Protein Metabolic Process Cytosol Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein-N-terminal Glutamine Amidohydrolase Activity Response To Estradiol Response To Monosaccharide Anterior Neural Tube Closure Cytoplasm Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Carbohydrate Response To Glucose Cellular Response To Staurosporine Luteolysis Glial Cell Apoptotic Process Phospholipase A2 Activator Activity Response To Hormone Eukaryotic Translation Elongation Factor 1 Complex Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Response To Nutrient Biotin Metabolic Process Biotin Binding Response To Biotin Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Response To Anesthetic Protein Processing Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Death-inducing Signaling Complex Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Carbon Catabolite Regulation Of Transcription Regulation Of Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity
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