PRDM5 and CLCN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRDM5	CLCN1
Description		PR/SET domain 5	chloride voltage-gated channel 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex Chloride Channel Complex Sarcolemma
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Chromatin Organization Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extracellular Matrix Organization Cellular Response To Leukemia Inhibitory Factor	Monoatomic Ion Transport Chloride Transport Muscle Contraction Neuronal Action Potential Propagation Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways			Stimuli-sensing channels
Drugs
Diseases			Myotonia congenita, including: Autosomal dominant myotonia congenita (Thomsen disease); Autosomal recessive myotonia congenita (Becker disease); Fluctuating myotonia congenita; Myotonia levoir
GWAS		F-cell distribution in sickle cell anaemia ( 21326311) Fasting plasma glucose ( 17903298) Hemoglobin levels ( 33491795) Loneliness (multivariate analysis) ( 27629369) Monobrow thickness ( 26926045) Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Sensorimotor dexterity ( 31596458)
Interacting Genes		7 interacting genes: ADPRS CLCN1 FAAP20 FBXO44 RASD1 TYK2 VIPR1	7 interacting genes: AHSA1 APPBP2 CIDEB FAM9B FKBP8 PRDM5 STIP1
Entrez ID		11107	1180
HPRD ID		17902	00320
Ensembl ID		ENSG00000138738	ENSG00000188037
Uniprot IDs		Q9NQX1	P35523
PDB IDs		6XAZ	6COY 6COZ 6QV6 6QVB 6QVC 6QVD 6QVU 8WXI 8WXJ
Enriched GO Terms of Interacting Partners?		ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Interleukin-12 Receptor Complex Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Poly(ADP-ribose) Glycohydrolase Activity Voltage-gated Chloride Channel Activity Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Receptor Complex Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Response To Superoxide Response To Oxygen Radical Protein De-ADP-ribosylation O-acetyl-ADP-ribose Deacetylase Activity Ubiquitin-modified Protein Reader Activity Action Potential Propagation Neuronal Action Potential Propagation	Hsp90 Protein Binding Protein Folding Chaperone
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