RHBDL2 and MAP7D1

Data Source: HiPPIP (Novel)

		RHBDL2	MAP7D1
Name		rhomboid like 2	MAP7 domain containing 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Cytoskeleton Midbody
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	None
	Biological Process	Proteolysis	Microtubule Cytoskeleton Organization
GWAS		Beard thickness ( 26926045 ) Menopause (age at onset) ( 22267201 26414677 ) Severe autoimmune type 2 diabetes ( 34737425 ) Sweet beverage consumption ( 31046077 ) Triglyceride levels ( 32203549 )	PR interval ( 32439900 )
Novel Interactors		1 novel interactors: MAP7D1	6 novel interactors: ADPRS AIRIM AKIRIN1 EVA1B RHBDL2 YRDC
Interacting Genes		4 interacting genes: EFNB2 EFNB3 SLC35B4 TMBIM6	10 interacting genes: APOA1 ATN1 CEBPA CLIP4 COPS6 GPRASP1 OGT RBM48 SRPK2 UBC
Entrez ID		54933	55700
HPRD ID		07151	07666
Ensembl ID		ENSG00000158315	ENSG00000116871
Uniprot IDs		B7Z1Y9 Q9NX52	B3KU03 D3DPS3 Q3KQU3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		T Cell Costimulation Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Virus Receptor Activity Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity Positive Regulation Of Aorta Morphogenesis Presynaptic Membrane Symbiont Entry Into Host Cell Negative Regulation Of Neuron Projection Development Endoribonuclease Inhibitor Activity Biological Process Involved In Interaction With Host UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transport Negative Regulation Of Cell Projection Organization Regulation Of Aorta Morphogenesis Negative Regulation Of Calcium Ion Transport Into Cytosol Neuron Projection Guidance Axon Guidance Positive Regulation Of Artery Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of T Cell Activation Venous Blood Vessel Morphogenesis Nephric Duct Morphogenesis Regulation Of Artery Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cardiac Muscle Cell Differentiation IRE1-mediated Unfolded Protein Response Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Lymph Vessel Development Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Presynapse Assembly Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Immunoglobulin Production Positive Regulation Of Cardiocyte Differentiation Transmembrane-ephrin Receptor Activity Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	None