PHLPP1 and ZCCHC2

Data Source: HiPPIP (Novel)

		PHLPP1	ZCCHC2
Name		PH domain and leucine rich repeat protein phosphatase 1	zinc finger CCHC-type containing 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Nucleic Acid Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Regulation Of T Cell Anergy Apoptotic Process Entrainment Of Circadian Clock Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of P38MAPK Cascade	None
Pathways		Negative regulation of the PI3K/AKT network	None
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288 ) Hip circumference adjusted for BMI ( 28552196 ) Plateletcrit ( 32888494 )	A body shape index ( 34021172 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Bipolar disorder ( 31043756 33263727 ) Breastfeeding duration ( 25475840 ) Chronotype ( 30696823 ) Cognitive function in longevity ( 33607172 ) Menopause (age at onset) ( 29773799 ) Morning person ( 30696823 ) Pulse pressure ( 30224653 ) Serum albumin levels ( 23022100 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		2 novel interactors: SERPINB7 ZCCHC2	7 novel interactors: ERCC1 HMSD MDM4 PHLPP1 PIGN RELCH SERPINB7
Interacting Genes		6 interacting genes: BRAP CSNK1A1 GSK3B NHERF1 TRIM11 WDR48	2 interacting genes: RNF10 SHANK3
Entrez ID		23239	54877
HPRD ID		15145	11696
Ensembl ID		ENSG00000081913	ENSG00000141664
Uniprot IDs		O60346	Q9BRD4 Q9C0B9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Negative Regulation Of Protein-containing Complex Assembly Maintenance Of Cell Polarity Negative Regulation Of Wnt Signaling Pathway Viral Protein Processing Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Negative Regulation Of TOR Signaling TOR Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein-containing Complex Assembly Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Establishment Of Cell Polarity Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Platelet-derived Growth Factor Production Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Negative Regulation Of AIM2 Inflammasome Complex Assembly Beta-catenin Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Platelet-derived Growth Factor Production Type 3 Metabotropic Glutamate Receptor Binding Regulation Of TOR Signaling Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Process Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Protein Modification Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of TORC2 Signaling Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity	None