ESRP1 and ARID5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ESRP1	ARID5A
Description		epithelial splicing regulatory protein 1	AT-rich interaction domain 5A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Ribonucleoprotein Complex	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Estrogen Receptor Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding Sequence-specific DNA Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding
	Biological Process	MRNA Processing RNA Splicing Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Regulation Of RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Chondrocyte Differentiation Immune System Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Estrogen Stimulus Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Signaling by BRAF and RAF1 fusions FGFR2 alternative splicing
Drugs
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Urate levels ( 31578528)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Event-related brain oscillations ( 21184583)
Interacting Genes		49 interacting genes: ALG13 ARID5A ATXN1 DAZAP2 H19 KLHDC7B KRTAP19-5 MED25 MIR106A MIR106B MIR128-2 MIR138-1 MIR138-2 MIR141 MIR155 MIR15B MIR19B1 MIR19B2 MIR200A MIR200C MIR20B MIR21 MIR222 MIR25 MIR29C MIR34A MIR34B MIR363 MIR7-1 MIR9-1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7F2 MIRLET7G MIRLET7I MRPS24 OXER1 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS2 ZC3H10	127 interacting genes: ACTMAP ANKRD11 AR ATP6V0D2 ATXN1 ATXN1L BAG4 BAHD1 BANP BOLL C14orf119 CAMK2A CATSPER1 CCDC120 CCDC57 CKS1B COX5B CRYBA1 CRYBA2 CYSRT1 DAB1 DAZAP2 DOK6 DTX2 ESR2 ESRP1 FAM168B FHL3 FOXD2 FOXH1 GATA5 GLIS2 GOLGA2 GRB2 HDAC7 HOXA1 HSD3B7 INIP IRX6 KAZN KCTD9 KDF1 KRT40 KRTAP10-8 KRTAP12-2 KRTAP12-4 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LENG8 LIMS3 LIMS4 LITAF LMO2 MAB21L2 MAGED1 MDFI MIEN1 MKRN3 MORN3 MYLIP NUDT22 ODAM OLIG3 OTX1 PHF1 PIBF1 PIN1 PITX1 PLA2G10 PLAGL2 PLEKHN1 PNMA1 POU1F1 PRDM6 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RARA RBFOX1 RBPMS RBPMS2 RFC5 RHOXF2 RNF44 ROR2 RXRA SEC24A SH2D2A SMYD1 SOHLH1 SOX5 TEKT3 TEKT4 TENT5A TENT5D TGM7 THRA TNS2 TRAF1 TRIM27 TRIM73 TSC1 TSEN15 TSSK3 UBTD2 USP20 VAC14 VENTX ZC3H10 ZIC1 ZNF503 ZNF765
Entrez ID		54845	10865
HPRD ID		07881	12481
Ensembl ID		ENSG00000104413	ENSG00000196843
Uniprot IDs		A0A2U3TZN9 Q6NXG1	Q03989
PDB IDs		2DHA 2RVJ 7VKI 7VKJ 7WRN
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Endothelial Cell Migration Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Negative Regulation Of Locomotion Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis	Intermediate Filament Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Identical Protein Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Migration POZ Domain Binding Regulation Of Gene Expression Chromatin Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Retinoic Acid Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Zinc Ion Binding Nucleus Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System
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