KRT32 and GATAD2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT32	GATAD2A
Description		keratin 32	GATA zinc finger domain containing 2A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleus Nucleoplasm Chromosome NuRD Complex Nuclear Speck
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation
Pathways		Keratinization Formation of the cornified envelope	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 31562340 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mild age-related type 2 diabetes ( 34737425) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		17 interacting genes: CCDC187 GATAD2A KIFC3 KRT2 KRT3 KRT5 KRT6B KRT72 KRT75 KRT76 KRT78 KRT8 KRT80 KRT86 NEDD9 TCHP UBASH3A	15 interacting genes: CBFA2T3 CEBPA CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 PAK4 SPOP
Entrez ID		3882	54815
HPRD ID		04134	11741
Ensembl ID		ENSG00000108759	ENSG00000167491
Uniprot IDs		Q14532	Q86YP4
PDB IDs			2L2L
Enriched GO Terms of Interacting Partners?		Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Intermediate Filament Cytoskeleton Cytosol Structural Constituent Of Cytoskeleton Epidermis Development Desmosome Intermediate Filament Polymerization Cornified Envelope Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Positive Regulation Of Immunological Synapse Formation Scaffold Protein Binding Zonula Adherens Maintenance	Chromatin Remodeling Chromatin Organization N-terminal Peptidyl-lysine Acetylation Structural Constituent Of Chromatin Nucleosome Chromosome Response To Nutrient Levels Epigenetic Regulation Of Gene Expression Response To Bisphenol A Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Intermediate Filament Organization Ventricular Cardiac Muscle Tissue Development Regulation Of DNA Repair Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process NuRD Complex Acetyltransferase Activity Protein-containing Complex Nucleosome Assembly Hematopoietic Stem Cell Proliferation Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Methyl-CpG Binding Nucleosome Organization Granulocyte Differentiation Positive Regulation Of DNA Repair Histone Acetyltransferase Activity Heterochromatin Formation Protein Acetylation DNA Methylation-dependent Constitutive Heterochromatin Formation Intermediate Filament Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Nucleosomal DNA Binding Inositol-3-phosphate Synthase Activity Nucleoplasm DNA-binding Transcription Factor Binding Structural Molecule Activity Protein-DNA Complex Assembly Heterochromatin Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Glycolytic Process Response To Vitamin B2
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