NDUFB11 and HIBADH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NDUFB11	HIBADH
Name		NADH:ubiquinone oxidoreductase subunit B11	3-hydroxyisobutyrate dehydrogenase
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity NADP Binding NAD Binding
	Biological Process	Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis	L-valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways		Respiratory electron transport Complex I biogenesis	Branched-chain amino acid catabolism
Drugs		None	NADH
GWAS		No GWAS studies recorded	Alcohol consumption (drinks per week) ( 30643258 ) Asthma ( 31959851 ) Diastolic blood pressure ( 27841878 ) General risk tolerance (MTAG) ( 30643258 ) Kidney stones ( 31729369 ) Lead levels in blood ( 25820613 ) Pulse pressure ( 27841878 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Systolic blood pressure ( 27841878 )
Interacting Genes		11 interacting genes: BAG6 CLDN7 EBP FATE1 GJB1 GPR101 GPR152 GPR42 HIBADH PPBP TIMMDC1	39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Entrez ID		54539	11112
HPRD ID		02323	12238
Ensembl ID		ENSG00000147123	ENSG00000106049
Uniprot IDs		Q9NX14	A0A024RA75 P31937
PDB IDs		5XTC 5XTD 5XTH 5XTI	2GF2 2I9P
GO Terms Enriched among Interactors		None	Membrane Endoplasmic Reticulum Membrane Establishment Of Protein Localization Endoplasmic Reticulum Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNAP Receptor Activity Establishment Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Intracellular Protein Localization Clathrin-coated Endocytic Vesicle Membrane