WIPI1

Description		WD repeat domain, phosphoinositide interacting 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Phagophore Assembly Site Autophagosome Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Endosome Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Phagophore Assembly Site Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Nuclear Estrogen Receptor Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Nuclear Androgen Receptor Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Vesicle Targeting, Trans-Golgi To Endosome Glycophagy Positive Regulation Of Autophagosome Assembly
Pathways		Macroautophagy XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		5 interacting genes: AR ESR1 ESR2 KCTD15 PPA1
Entrez ID		55062
HPRD ID		08540
Ensembl ID		ENSG00000070540
Uniprot IDs		B4DX63 G5EA37 Q5MNZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Estrogen Response Element Binding Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Nuclear Receptor Activity Nuclear Estrogen Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Prostate Gland Growth Hormone-mediated Signaling Pathway Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Prostate Gland Epithelium Morphogenesis Intracellular Receptor Signaling Pathway Cellular Response To Estradiol Stimulus Lipid Binding Organ Growth Transcription Coactivator Binding Regulation Of Morphogenesis Of A Branching Structure Enzyme Binding Response To Estrogen Negative Regulation Of DNA-templated Transcription Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Cellular Response To Lipid Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process ATPase Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Induction Male Somatic Sex Determination Beta-catenin Binding Male Gonad Development Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Gonad Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Response To Lipid Epithelial Cell Proliferation Regulation Of Reproductive Process Male Genitalia Morphogenesis
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