PARP14 and PARP10

Number of citations of the paper that reports this interaction (PubMedID 23473667)
0

Data Source:
BioGRID (pull down)

		PARP14	PARP10
Description		poly(ADP-ribose) polymerase family member 14	poly(ADP-ribose) polymerase family member 10
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+ Binding NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding DNA-binding Transcription Factor Binding NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Immune System Process Negative Regulation Of Gene Expression Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Interleukin-4-mediated Signaling Pathway	DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression Viral Protein Processing Translesion Synthesis Negative Regulation Of NF-kappaB Transcription Factor Activity NAD+ Biosynthetic Process Via The Salvage Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fibroblast Proliferation Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Hip index ( 34021172) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: GPI PARP10	14 interacting genes: AURKA DTX2 H2AC20 H2BC21 H3-3A H3C1 H4C1 MYC PARP14 PCNA PLK1 RAN RNF26 UBC
Entrez ID		54625	84875
HPRD ID		11421	15100
Ensembl ID		ENSG00000173193	ENSG00000178685
Uniprot IDs		Q460N5 Q8N546	B4E0C4 E9PK67 E9PNI7 E9PPE7 Q53GL7
PDB IDs		3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W 6WE2 6WE3 6WE4 7D2C 7L9Y 7LUN 7R3L	2DHX 3HKV 5LX6 6FXI
Enriched GO Terms of Interacting Partners?		Nicotinamide Nucleotide Metabolic Process Glucose-6-phosphate Isomerase Activity Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Monosaccharide Binding Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Negative Regulation Of Protein K63-linked Ubiquitination NAD+-protein-lysine ADP-ribosyltransferase Activity Fructose 6-phosphate Metabolic Process Carbohydrate Derivative Binding Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Erythrocyte Homeostasis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Atrial Septum Development Kidney Morphogenesis NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Protein Polyubiquitination Protein Auto-ADP-ribosylation NAD+ Biosynthetic Process Via The Salvage Pathway NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Protein K63-linked Ubiquitination Glycolytic Process Through Glucose-6-phosphate Response To Immobilization Stress Nucleobase-containing Small Molecule Metabolic Process Nucleoside Phosphate Metabolic Process Response To Muscle Stretch Purine-containing Compound Metabolic Process Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Glucose Catabolic Process Canonical Glycolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Polyubiquitination NAD+ Biosynthetic Process Viral Protein Processing Translesion Synthesis Pyridine Nucleotide Biosynthetic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Protein Poly-ADP-ribosylation K63-linked Polyubiquitin Modification-dependent Protein Binding	Chromosome Organization Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Chromatin Organization Chromatin Remodeling Chromosome Nucleosome Assembly Telomere Organization Nucleosome Organization Protein-DNA Complex Assembly Nucleoplasm Nucleus Organelle Organization Centrosome Separation Epigenetic Regulation Of Gene Expression Mitotic Spindle Organization Extracellular Exosome Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Cell Cycle Protein Localization To Centrosome Spindle Midzone Mitotic Cell Cycle Phase Transition Protein-containing Complex Liver Regeneration Cell Cycle Phase Transition Spindle Organization Centriole Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Regulation Of Cell Division Post-translational Protein Modification Mitotic Sister Chromatid Segregation Midbody Mitotic Spindle Pole Sister Chromatid Segregation Spindle Microtubule Peptidyl-serine Phosphorylation DNA Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding PCNA Complex Replisome Male Germ Cell Nucleus Protein Localization To Cytoskeleton Centrosome Cycle Protein Localization To Chromatin G2/M Transition Of Mitotic Cell Cycle
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