POLR2L and POLR2G

Number of citations of the paper that reports this interaction (PMID 9201987)
16

Data Source:
BioGRID (pull down)

		POLR2L	POLR2G
Gene Name		polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	polymerase (RNA) II (DNA directed) polypeptide G
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Nucleolus
	Molecular Function	RNA Polymerase I Activity RNA Polymerase II Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding	Single-stranded DNA Binding Single-stranded RNA Binding DNA-directed RNA Polymerase Activity Translation Initiation Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription RNA Splicing Gene Expression Viral Process Positive Regulation Of Type I Interferon Production PiRNA Metabolic Process Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription	Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Apoptotic Process RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Translational Initiation Positive Regulation Of Viral Transcription Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation Abortive elongation of HIV-1 transcript in the absence of Tat RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Regulatory RNA pathways Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER Influenza Life Cycle RNA Polymerase III Transcription Termination HIV elongation arrest and recovery NoRC negatively regulates rRNA expression Influenza Viral RNA Transcription and Replication RNA Polymerase III Chain Elongation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation Transcription of the HIV genome Nucleotide Excision Repair PIWI-interacting RNA (piRNA) biogenesis mRNA Splicing RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Innate Immune System RNA Polymerase III Transcription Initiation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Pausing and recovery of HIV elongation Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation	RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: BANP CCDC85B CHEK2 COIL EXOSC5 L3MBTL3 NFKBIB NOV PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2H REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 ZBTB14	21 interactors: ATF7IP DDX54 EWSR1 FNDC4 MCM3AP MYOD1 NOTCH2NL NTRK2 POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H POLR2K POLR2L PRKRA STK19 TAF15 TNNC1 VHL
Entrez ID		5441	5436
HPRD ID		01155	15995
Ensembl ID		ENSG00000177700	ENSG00000168002
Uniprot IDs		P62875	P62487
PDB IDs			2C35
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Stem Cell Maintenance Regulation Of Viral Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process NcRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Stem Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Metabolic Process RNA Splicing Cellular Nitrogen Compound Metabolic Process DNA Repair Transcription From RNA Polymerase II Promoter MRNA Processing Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Viral Process Cellular Response To DNA Damage Stimulus Regulation Of RNA Metabolic Process RNA Processing Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cell Development	7-methylguanosine MRNA Capping Transcription Elongation From RNA Polymerase II Promoter PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Stem Cell Maintenance Regulation Of Viral Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Viral Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Termination Of RNA Polymerase I Transcription Stem Cell Development Positive Regulation Of Gene Expression Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase I Promoter Stem Cell Differentiation RNA Splicing Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase III Promoter Transcription From RNA Polymerase II Promoter MRNA Processing NcRNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Termination DNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production MRNA Metabolic Process Cellular Response To Stress Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process DNA Repair Regulation Of Gene Expression Regulation Of Type I Interferon Production
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