GDAP1 and CLCN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GDAP1	CLCN7
Description		ganglioside induced differentiation associated protein 1	chloride voltage-gated channel 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Cytosol Membrane	Lysosome Lysosomal Membrane Membrane Chloride Channel Complex
	Molecular Function	Protein Binding	Nucleotide Binding Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Chloride:proton Antiporter Activity
	Biological Process	Mitochondrial Fission Protein Targeting To Mitochondrion Mitochondrial Fusion Response To Retinoic Acid Cellular Response To Vitamin D	Monoatomic Ion Transport Chloride Transport Response To PH Transepithelial Chloride Transport Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport
Pathways		Class I peroxisomal membrane protein import	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Dysmenorrheic pain ( 27454463) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 32499647) Waist circumference ( 17903300)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: ABHD16A APOD CLCN7 DCBLD2 FAM114A1 PNLIPRP1 STARD4 TMEM14B TMEM218 TUBB	16 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		54332	1186
HPRD ID		05963	04103
Ensembl ID		ENSG00000104381	ENSG00000103249
Uniprot IDs		A0A6Q8PEZ4 A0A6Q8PH97 B4DIH2 Q8TB36	P51798
PDB IDs		7AIA 7ALM 7B2G 7Q6J 7Q6K 7YWD 8A4J 8A4K	7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT
Enriched GO Terms of Interacting Partners?		Acylglycerol Catabolic Process Cholesterol Binding Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Chloride:proton Antiporter Activity Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Lipid Transport Involved In Lipid Storage Cholesterol Transport Involved In Cholesterol Storage Positive Regulation Of Bile Acid Biosynthetic Process	Membrane Protein-membrane Adaptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Monoatomic Ion Transport
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