CLCN7 and LYVE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCN7	LYVE1
Description		chloride voltage-gated channel 7	lymphatic vessel endothelial hyaluronan receptor 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Chloride Channel Complex	Plasma Membrane Membrane Extracellular Exosome Cell Periphery
	Molecular Function	Nucleotide Binding Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Chloride:proton Antiporter Activity	Transmembrane Signaling Receptor Activity Protein Binding Hyaluronic Acid Binding Signaling Receptor Activity Cargo Receptor Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Response To PH Transepithelial Chloride Transport Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport	Positive Regulation Of Cellular Extravasation Glycosaminoglycan Catabolic Process Receptor-mediated Endocytosis Cell Adhesion Cell-matrix Adhesion Response To Wounding Anatomical Structure Morphogenesis Hyaluronan Catabolic Process
Pathways		Stimuli-sensing channels	Hyaluronan metabolism Hyaluronan degradation
Drugs			Hyaluronic acid
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Blood protein levels ( 30072576)
Interacting Genes		16 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	26 interacting genes: AIG1 AQP10 CLCN7 CYSRT1 EMP3 KRT34 KRTAP10-3 KRTAP10-8 KRTAP12-3 KRTAP6-2 KRTAP9-2 NBPF19 NINJ2 NOTCH2NLA NRSN1 PDGFB PIGF SERP2 SLC30A2 SLC38A7 SLC41A2 THSD7A THSD7B UBE2J1 VEGFA YIPF6
Entrez ID		1186	10894
HPRD ID		04103	05753
Ensembl ID		ENSG00000103249	ENSG00000133800
Uniprot IDs		P51798	B2R672 Q9Y5Y7
PDB IDs		7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT	8OS2 8OXD
Enriched GO Terms of Interacting Partners?		Membrane Protein-membrane Adaptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Monoatomic Ion Transport	Intermediate Filament Keratin Filament Positive Regulation Of Protein Autophosphorylation Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor Binding Monoatomic Cation Transmembrane Transporter Activity
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