CLCN7 and GDAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCN7	GDAP1
Description		chloride voltage-gated channel 7	ganglioside induced differentiation associated protein 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Chloride Channel Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Nucleotide Binding Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Chloride:proton Antiporter Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Response To PH Transepithelial Chloride Transport Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport	Mitochondrial Fission Protein Targeting To Mitochondrion Mitochondrial Fusion Response To Retinoic Acid Cellular Response To Vitamin D
Pathways		Stimuli-sensing channels	Class I peroxisomal membrane protein import
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Dysmenorrheic pain ( 27454463) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 32499647) Waist circumference ( 17903300)
Interacting Genes		16 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	10 interacting genes: ABHD16A APOD CLCN7 DCBLD2 FAM114A1 PNLIPRP1 STARD4 TMEM14B TMEM218 TUBB
Entrez ID		1186	54332
HPRD ID		04103	05963
Ensembl ID		ENSG00000103249	ENSG00000104381
Uniprot IDs		P51798	A0A6Q8PEZ4 A0A6Q8PH97 B4DIH2 Q8TB36
PDB IDs		7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT	7AIA 7ALM 7B2G 7Q6J 7Q6K 7YWD 8A4J 8A4K
Enriched GO Terms of Interacting Partners?		Membrane Protein-membrane Adaptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Monoatomic Ion Transport	Acylglycerol Catabolic Process Cholesterol Binding Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Chloride:proton Antiporter Activity Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Lipid Transport Involved In Lipid Storage Cholesterol Transport Involved In Cholesterol Storage Positive Regulation Of Bile Acid Biosynthetic Process
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