CLCN7 and OSTM1

Number of citations of the paper that reports this interaction (PubMedID 16525474)
0

Data Source:
HPRD (in vivo)

		CLCN7	OSTM1
Description		chloride voltage-gated channel 7	osteoclastogenesis associated transmembrane protein 1
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Chloride Channel Complex	Lysosome Lysosomal Membrane Cytosol Membrane Chloride Channel Complex
	Molecular Function	Nucleotide Binding Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Chloride:proton Antiporter Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Response To PH Transepithelial Chloride Transport Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport	Osteoclast Differentiation Transepithelial Chloride Transport
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Major depressive disorder ( 29187746) Psoriasis ( 31376382)
Interacting Genes		16 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	7 interacting genes: CFTR CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20
Entrez ID		1186	28962
HPRD ID		04103	09628
Ensembl ID		ENSG00000103249	ENSG00000081087
Uniprot IDs		P51798	A0A8V8TNX7 A0A8V8TPT7 Q86WC4
PDB IDs		7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT	7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT
Enriched GO Terms of Interacting Partners?		Membrane Protein-membrane Adaptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Monoatomic Ion Transport	Chloride Transmembrane Transporter Activity Transepithelial Transport Chloride Channel Complex Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency GTPase Activity Inorganic Anion Transport Monoatomic Anion Transmembrane Transport Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Chloride Transmembrane Transport Inorganic Anion Transmembrane Transport Chloride Transport Positive Regulation Of Monoatomic Anion Transport Monoatomic Anion Transport Chloride:proton Antiporter Activity DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Transepithelial Water Transport Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Tooth Mineralization Nucleotide-excision Repair, DNA Gap Filling Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA-dependent Protein Kinase-DNA Ligase 4 Complex G Protein-coupled Receptor Signaling Pathway Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transepithelial Chloride Transport Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair GTPase Activator Activity Lymphoid Progenitor Cell Differentiation AMP Binding Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?