NEIL1

Description		nei like DNA glycosylase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Nucleic Acid Binding DNA Binding Damaged DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Damage Response Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1
Drugs		Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: MAP3K11
Interacting Genes		5 interacting genes: APP HUS1 POLB RAD1 XRCC1
Entrez ID		79661
HPRD ID		12314
Ensembl ID		ENSG00000140398
Uniprot IDs		Q96FI4
PDB IDs		1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY 6LWA 6LWB 6LWC 6LWD 6LWF 6LWG 6LWH 6LWI 6LWJ 6LWK 6LWL 6LWM 6LWN 6LWO 6LWP 6LWQ 6LWR 7TMX 8FTJ
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Damaged DNA Binding Meiotic Cell Cycle Checkpoint Signaling Response To Radiation DNA Repair Response To Ionizing Radiation Intracellular Signal Transduction DNA Metabolic Process Double-strand Break Repair DNA Damage Response DNA Recombination Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Enzyme Binding Positive Regulation Of Neuron Apoptotic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Ionizing Radiation Oxidized DNA Binding Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Telomere Maintenance DNA Damage Checkpoint Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Stress Telomere Organization Meiotic DNA Integrity Checkpoint Signaling Immunoglobulin Heavy Chain V-D-J Recombination Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Regulation Of JNK Cascade Signal Transduction In Response To DNA Damage
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