HIVEP2 and BRWD1

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		HIVEP2	BRWD1
Name		HIVEP zinc finger 2	bromodomain and WD repeat domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Cell Projection Ciliary Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape
Pathways		None	Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
GWAS		Adiponectin levels ( 24105470 ) Adult body size ( 32376654 ) Adverse response to inhaled corticosteroid treatment x age interaction in asthma ( 32119686 ) Age at first birth ( 34211149 ) Asthma ( 32296059 ) Bipolar disorder ( 31043756 ) Coronary artery disease ( 29212778 ) Daytime sleep phenotypes ( 27126917 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Gastroesophageal reflux disease ( 34187846 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391 ) Mood instability ( 31168069 ) Pit-and-Fissure caries ( 24556642 ) Platelet distribution width ( 32888494 ) Type 2 diabetes ( 32499647 ) Weight ( 28552196 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 33547301 ) Apolipoprotein B levels ( 32203549 ) Cognitive function ( 25644384 ) Daytime nap ( 33568662 ) Daytime sleep phenotypes ( 27126917 ) General cognitive ability ( 29844566 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Menarche (age at onset) ( 25231870 ) Platelet distribution width ( 32888494 ) Smoking initiation ( 33082346 ) Temperament (bipolar disorder) ( 22365631 ) Total cholesterol levels ( 30275531 )
Novel Interactors		1 novel interactors: PAX6	2 novel interactors: ADD2 EIF4E
Interacting Genes		8 interacting genes: BRWD1 BTG3 CREBBP LINC01554 MTNR1A RFX1 RSPH1 YWHAE	18 interacting genes: APP APPL1 CALM1 COPS5 CUL4B FNDC3B HDAC7 HIVEP2 NRF1 NUTF2 PPP5C SMARCA4 SMARCD1 STAT3 SYT4 TAF1 TRIM55 TRIM63
Entrez ID		3097	54014
HPRD ID		00881	11683
Ensembl ID		ENSG00000010818	ENSG00000185658
Uniprot IDs		P31629	Q9NSI6
PDB IDs		Not available	3Q2E
GO Terms Enriched among Interactors		None	Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Astrocyte Projection Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Cycle Process Titin Binding Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway NBAF Complex RSC-type Complex NpBAF Complex Regulation Of Cell Cycle Phase Transition GBAF Complex Protein Modification By Small Protein Conjugation Response To Lead Ion Modulation Of Chemical Synaptic Transmission Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleosome Disassembly Negative Regulation Of Glycolytic Process Epigenetic Regulation Of Gene Expression Neuronal Dense Core Vesicle Protein-DNA Complex Disassembly Post-translational Protein Modification Regulation Of Cellular Response To Stress Protein Import Into Nucleus Negative Regulation Of ATP Metabolic Process Regulation Of Endocytosis Nucleoplasm Import Into Nucleus Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process