PPIL3 and STRADB

		PPIL3	STRADB
Description		peptidylprolyl isomerase like 3	STE20 related adaptor beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleus Cytoplasm Cytosol Aggresome Serine/threonine Protein Kinase Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing	Cell Morphogenesis Protein Phosphorylation Protein Export From Nucleus JNK Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		mRNA Splicing - Major Pathway	Energy dependent regulation of mTOR by LKB1-AMPK
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1	8 interacting genes: CAB39 GRB2 MAP3K7 NEB STK11 TRAF6 UBC XIAP
Entrez ID		53938	55437
HPRD ID		15163	09546
Ensembl ID		ENSG00000240344	ENSG00000082146
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	Q9C0K7
PDB IDs		1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?			Protein Serine/threonine Kinase Binding Immune Response-activating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical NF-kappaB Signal Transduction Interleukin-17A-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Anoikis Positive Regulation Of JUN Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway T Cell Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Modification Process DNA Damage Response Regulation Of Type I Interferon Production Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Serine/threonine Protein Kinase Complex Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway P38MAPK Cascade Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Cellular Response To Stress Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Activation Of Innate Immune Response Activation Of Protein Kinase Activity Regulation Of T Cell Cytokine Production Protein Kinase Activator Activity Toll-like Receptor 4 Signaling Pathway
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