DHX37

Description		DEAH-box helicase 37
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Membrane Small-subunit Processome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity U3 SnoRNA Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Brain Development Ribosome Biogenesis Ribosome Assembly Ribosomal Small Subunit Biogenesis Positive Regulation Of Male Gonad Development
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Hip circumference ( 28552196) Insulin levels in response to oral glucose tolerance test (120 minutes) ( 29093273)
Interacting Genes		56 interacting genes: ATXN1 EIF4ENIF1 KIFAP3 KRT31 MIR1-1 MIR1-2 MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR29A MIR34A MIR34B MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PLXNA2 RGS17 TRIP6
Entrez ID		57647
HPRD ID		10883
Ensembl ID		ENSG00000150990
Uniprot IDs		Q8IY37
PDB IDs		7MQA
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Gene Expression Negative Regulation Of Cell Migration Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility MRNA Destabilization RNA Destabilization Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Growth Factor Stimulus
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