PLAGL2 and PHC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLAGL2	PHC2
Description		PLAG1 like zinc finger 2	polyhomeotic homolog 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Post-embryonic Development Chylomicron Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Spermatogenesis Negative Regulation Of DNA-templated Transcription
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)	Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Blood urea nitrogen levels ( 29403010 31152163) General risk tolerance (MTAG) ( 30643258) Pancreas volume ( 34128465) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		45 interacting genes: ANKRD11 ARID5A BCAS2 CATSPER1 CCDC120 CTNNA3 DAPP1 DHX57 DVL3 FAM161B FAM83A FAM90A1 GADD45G GEM GLYCTK GPATCH2L GYS1 INO80B IRX2 KANK2 MAD2L2 MAPK1 MORN4 NOS1AP OIP5 OLIG3 PAX9 PHC2 PIN1 PLAC8 PRR35 RCHY1 RHOBTB3 RIPPLY1 SAMD11 SEPHS1 SMARCD1 TEKT3 TEKT4 TRAF4 TRIM41 VEZF1 YPEL5 ZNF564 ZNF581	78 interacting genes: AEN AFG3L2 AIRIM AP1M1 BMI1 BSDC1 BYSL CARD9 CRK CRKL DNMT1 DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB FXR1 FXR2 GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF3 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417
Entrez ID		5326	1912
HPRD ID		05333	10340
Ensembl ID		ENSG00000126003	ENSG00000134686
Uniprot IDs		Q9UPG8	A0A0A0MSI2 A0A994J5J9 Q8IXK0
PDB IDs
Enriched GO Terms of Interacting Partners?			Nucleus Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process PRC1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Metabolic Process Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Diapedesis Negative Regulation Of Biosynthetic Process PcG Protein Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Remodeling Identical Protein Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Rac Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Helper T Cell Diapedesis DNA-binding Transcription Factor Binding Response To Ionizing Radiation RING-like Zinc Finger Domain Binding Cerebellar Neuron Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Protein Localization To Nucleus U2-type Precatalytic Spliceosome Heterochromatin Response To Muramyl Dipeptide Regulation Of Macromolecule Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Histone Binding Metal Ion Binding Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Ephrin Receptor Binding Promoter-specific Chromatin Binding MLL1 Complex
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