PIGH and PIGA

Number of citations of the paper that reports this interaction (PubMedID 9463366)
41

Data Source:
HPRD (in vitro, in vivo)

		PIGH	PIGA
Description		phosphatidylinositol glycan anchor biosynthesis class H	phosphatidylinositol glycan anchor biosynthesis class A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Catalytic Activity Protein Binding	Protein Binding UDP-glycosyltransferase Activity Transferase Activity Glycosyltransferase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein Modification Process	GPI Anchor Biosynthetic Process Lipid Metabolic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases			Paroxysmal nocturnal hemoglobinuria (PNH)
GWAS
Interacting Genes		3 interacting genes: PIGA PIGQ VKORC1	4 interacting genes: DPM2 PIGH PIGQ PIGY
Entrez ID		5283	5277
HPRD ID		02540	02410
Ensembl ID		ENSG00000100564	ENSG00000165195
Uniprot IDs		H0YLY9 Q14442	A0A2K4ZA02 P37287
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Endoplasmic Reticulum Membrane Membrane Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Endoplasmic Reticulum Glycerolipid Metabolic Process Phospholipid Metabolic Process Quinone Binding Carbohydrate Derivative Biosynthetic Process Vitamin K Metabolic Process Peptidyl-glutamic Acid Modification Lipid Biosynthetic Process Organophosphate Biosynthetic Process UDP-glycosyltransferase Activity Positive Regulation Of Coagulation Carbohydrate Derivative Metabolic Process Organophosphate Metabolic Process Lipid Metabolic Process Bone Development Ketone Metabolic Process Cellular Response To Leukemia Inhibitory Factor Phosphate-containing Compound Metabolic Process Response To Leukemia Inhibitory Factor Coagulation Blood Coagulation Xenobiotic Metabolic Process Hemostasis	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Organophosphate Metabolic Process Endoplasmic Reticulum Membrane Phosphate-containing Compound Metabolic Process Terpenoid Metabolic Process Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Endoplasmic Reticulum Isoprenoid Metabolic Process Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Dolichol-phosphate-mannose Synthase Complex Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Dolichol Phosphate Mannose Biosynthetic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Amyloid-beta Clearance By Transcytosis Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Plasma Membrane Protein Complex Low-density Lipoprotein Particle Receptor Activity Lipoprotein Transport Astrocyte Activation Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding
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