PIGH and PIGQ

Number of citations of the paper that reports this interaction (PubMedID 9463366)
41

Data Source:
HPRD (in vitro)

		PIGH	PIGQ
Description		phosphatidylinositol glycan anchor biosynthesis class H	phosphatidylinositol glycan anchor biosynthesis class Q
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Catalytic Activity Protein Binding	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein Modification Process	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS			Disc degeneration (lumbar) ( 22993228) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		3 interacting genes: PIGA PIGQ VKORC1	4 interacting genes: PIGA PIGC PIGH SMAD1
Entrez ID		5283	9091
HPRD ID		02540	09307
Ensembl ID		ENSG00000100564	ENSG00000007541
Uniprot IDs		H0YLY9 Q14442	B2RAU6 Q9BRB3
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Endoplasmic Reticulum Membrane Membrane Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Endoplasmic Reticulum Glycerolipid Metabolic Process Phospholipid Metabolic Process Quinone Binding Carbohydrate Derivative Biosynthetic Process Vitamin K Metabolic Process Peptidyl-glutamic Acid Modification Lipid Biosynthetic Process Organophosphate Biosynthetic Process UDP-glycosyltransferase Activity Positive Regulation Of Coagulation Carbohydrate Derivative Metabolic Process Organophosphate Metabolic Process Lipid Metabolic Process Bone Development Ketone Metabolic Process Cellular Response To Leukemia Inhibitory Factor Phosphate-containing Compound Metabolic Process Response To Leukemia Inhibitory Factor Coagulation Blood Coagulation Xenobiotic Metabolic Process Hemostasis	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Homomeric SMAD Protein Complex Organophosphate Metabolic Process Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Lipid Metabolic Process Endoplasmic Reticulum Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Anti-Mullerian Hormone Receptor Signaling Pathway SMAD Protein Complex Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Phosphate-containing Compound Metabolic Process Catalytic Activity Primary MiRNA Binding Endoplasmic Reticulum Co-SMAD Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Primary MiRNA Processing Positive Regulation Of Dendrite Development I-SMAD Binding Cardiac Conduction System Development UDP-glycosyltransferase Activity Hindbrain Development SMAD Protein Signal Transduction Positive Regulation Of Sprouting Angiogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cartilage Development Midbrain Development MiRNA Processing Ureteric Bud Development Muscle Cell Proliferation Mesonephric Tubule Development Mesonephric Epithelium Development
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