CDK14 and ACVR1

Number of citations: 0 (PubMedID 15761153)
Data Source: HPRD (in vivo)

		CDK14	ACVR1
Name		cyclin dependent kinase 14	activin A receptor type 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cytoplasmic Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Plasma Membrane Membrane Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Peptide Hormone Binding Growth Factor Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cell Division Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition	Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Formation Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Mesoderm Development Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Circulatory System Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Regulation Of Multicellular Organismal Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Drugs		None	ATP Dorsomorphin Fostamatinib
Diseases		None	Fibrodysplasia ossificans progressiva (FOP)
GWAS		Circulating fibroblast growth factor 23 levels ( 30217807 ) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hepatitis B virus-related hepatocellular carcinoma ( 29246937 ) Pulse pressure ( 30224653 30578418 ) Serum thyroid-stimulating hormone levels ( 25436638 )	A body shape index ( 34021172 ) Severe gingival inflammation ( 28459102 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		13 interacting genes: ACVR1 BMPR1B CCND3 CCNY CDKN1A FBXO7 RB1 SEPTIN8 SMURF1 TGFBR1 YWHAB YWHAE YWHAQ	70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP CRIPTO DCAF6 DUSP13B ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SKIC8 SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1
Entrez ID		5218	90
HPRD ID		15121	00021
Ensembl ID		ENSG00000058091	ENSG00000115170
Uniprot IDs		B4DK59 E7EUK8 O94921	D3DPA4 Q04771
PDB IDs		Not available	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 5S75 5S76 5S77 5S78 5S79 5S7A 5S7B 5S7C 5S7D 5S7E 5S7F 5S7G 5S7H 5S7I 5S7J 5S7K 5S7L 5S7M 5S7N 5S7O 5S7P 5S7Q 5S7R 5S7S 5S7T 5S7U 5S7V 5S7W 5S7X 5S7Y 5S7Z 5S80 5S81 5S82 5S83 5S84 5S85 5S86 5S87 5S88 5S89 5S8A 5S8B 5S9K 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6UNQ 6UNR 6UNS 6Z36 6ZGC 7A21 7C3G 7NNS 7YRU 8C7W 8C7Z 8POD 8R7G 8UWR 9D8E 9D8F 9D8Z
GO Terms Enriched among Interactors		Regulation Of Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Protein Targeting Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Signal Transduction Phosphoprotein Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity Phosphoserine Residue Binding Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Developmental Process Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Activin Binding Protein Kinase Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity BMP Signaling Pathway Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Negative Regulation Of Activin Receptor Signaling Pathway I-SMAD Binding Negative Regulation Of Cell Cycle Process Cellular Response To Growth Factor Stimulus	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway GTP Binding Signal Transduction Regulation Of Signal Transduction Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus GTPase Activity Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Response To Growth Factor Cartilage Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Positive Regulation Of Cartilage Development Growth Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation GDP Binding Regulation Of Bone Mineralization Nucleotide Binding Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction SMAD Protein Signal Transduction Enzyme Activator Complex Intracellular Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Heart Development Regulation Of Osteoblast Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Tricuspid Valve Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Intracellular Signaling Cassette Morphogenesis Of A Branching Structure Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation