CDK14 and SGCE

Data Source: HiPPIP (Novel)

		CDK14	SGCE
Name		cyclin dependent kinase 14	sarcoglycan epsilon
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cytoplasmic Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Membrane Dendrite Dendrite Membrane Sarcolemma Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	None
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cell Division Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition	Cell-matrix Adhesion Muscle Organ Development
Pathways		None	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Circulating fibroblast growth factor 23 levels ( 30217807 ) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hepatitis B virus-related hepatocellular carcinoma ( 29246937 ) Pulse pressure ( 30224653 30578418 ) Serum thyroid-stimulating hormone levels ( 25436638 )	No GWAS studies recorded
Novel Interactors		3 novel interactors: CDK6 PDGFRB SGCE	10 novel interactors: AKAP9 CDK14 CDK6 CYP3A7 MED12 MTERF1 PDYN SEMA3C SYT13 TAC1
Interacting Genes		13 interacting genes: ACVR1 BMPR1B CCND3 CCNY CDKN1A FBXO7 RB1 SEPTIN8 SMURF1 TGFBR1 YWHAB YWHAE YWHAQ	4 interacting genes: ARIH2 CWC15 KEAP1 PPP1CC
Entrez ID		5218	8910
HPRD ID		15121	04999
Ensembl ID		ENSG00000058091	ENSG00000127990
Uniprot IDs		B4DK59 E7EUK8 O94921	A0A0S2Z4P5 A0A2R8Y448 A0A2R8Y5J3 A0A2R8YGQ3 B4DP78 C9JR67 E9PEH6 O43556
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Protein Targeting Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Signal Transduction Phosphoprotein Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity Phosphoserine Residue Binding Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Developmental Process Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Activin Binding Protein Kinase Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity BMP Signaling Pathway Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Negative Regulation Of Activin Receptor Signaling Pathway I-SMAD Binding Negative Regulation Of Cell Cycle Process Cellular Response To Growth Factor Stimulus	None