PEX1

Description		peroxisomal biogenesis factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Microtubule-based Peroxisome Localization
Pathways		Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Height ( 18391951) Hip circumference adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: IL6R
Interacting Genes		3 interacting genes: PEX26 PEX5 PEX6
Entrez ID		5189
HPRD ID		03682
Ensembl ID		ENSG00000127980
Uniprot IDs		A0A0C4DG33 B4DER6 O43933
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Receptor Metabolic Process Peroxisomal Membrane Protein Import Into Peroxisome Matrix, Translocation Protein Transmembrane Transport Protein Import Into Peroxisome Membrane Peroxisome Protein Targeting To Peroxisome Establishment Of Protein Localization To Organelle Intracellular Protein Transport Protein Localization To Organelle Ciliary Neurotrophic Factor Binding Hepatic Immune Response Interleukin-6 Binding Interleukin-6 Receptor Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Peroxisome Targeting Sequence Binding Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Protein Targeting Protein Transport Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Matrix, Docking Transmembrane Transport Ciliary Neurotrophic Factor-mediated Signaling Pathway Protein To Membrane Docking Intracellular Transport Vascular Endothelial Growth Factor Production Protein Import Into Peroxisome Matrix, Substrate Release Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding Positive Regulation Of Glomerular Mesangial Cell Proliferation Establishment Of Protein Localization Protein Localization To Membrane Positive Regulation Of Cell Proliferation Involved In Kidney Development Photoreceptor Cell Cilium Ubiquitin-modified Protein Reader Activity Protein Carrier Chaperone Protein-containing Complex Binding
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