PDYN and NRDC

Number of citations of the paper that reports this interaction (PubMedID 12590613)
0

Data Source:
HPRD (in vitro)

		PDYN	NRDC
Description		prodynorphin	nardilysin convertase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle	Mitochondrion Mitochondrial Matrix Cytosol Cell Surface Dendrite Cell Projection
	Molecular Function	Opioid Peptide Activity Protein Binding Opioid Receptor Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Epidermal Growth Factor Binding Endopeptidase Activator Activity
	Biological Process	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception	Proteolysis Positive Regulation Of Myelination Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Axonogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Aortic root size ( 21223598) Immune response to measles-mumps-rubella vaccine ( 24811271) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Platelet count ( 29403010)	Appendicular lean mass ( 33097823)
Interacting Genes		2 interacting genes: APP NRDC	6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC
Entrez ID		5173	4898
HPRD ID		08838	04036
Ensembl ID		ENSG00000101327	ENSG00000078618
Uniprot IDs		P01213	G3V1R5 O43847 Q6UUU9
PDB IDs		2N2F 7Y1F 8F7W 8VJU 8VJV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Membrane Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Epidermal Growth Factor Binding GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Sarcoglycan Complex Attachment Of GPI Anchor To Protein Cell Projection Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity	Cell-cell Signaling Cell Communication Signaling Neuronal Dense Core Vesicle Hippocampal Mossy Fiber To CA3 Synapse Regulation Of System Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Oxytocin Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Amylin Receptor 1 Signaling Pathway Calcitonin Receptor Binding Signaling Receptor Binding Endocytosis Amylin Receptor 2 Signaling Pathway Hormone Activity Insulin Receptor Complex Neuropeptide Signaling Pathway Opioid Receptor Binding Opioid Peptide Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Asymmetric, Glutamatergic, Excitatory Synapse Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse
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