SF3B6 and RPL4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SF3B6	RPL4
Description		splicing factor 3b subunit 6	ribosomal protein L4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Nuclear Body Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Blastocyst Formation MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	Cytoplasmic Translation Translation
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases
GWAS
Interacting Genes		6 interacting genes: APP CEBPA ERBB3 RPL4 SF3B1 U2AF2	21 interacting genes: APBB1 APOE DUX4 DUX4L9 FOXP1 IL32 MAP3K14 MDM2 MYB NDRG1 OGT PBX2 PIN1 PRDX2 PRPF40A RBFOX2 SF3B6 SORBS1 SUMO2 TNPO2 TSC2
Entrez ID		51639	6124
HPRD ID		09702	01607
Ensembl ID		ENSG00000115128	ENSG00000174444
Uniprot IDs		Q9Y3B4	P36578
PDB IDs		2F9D 2F9J 2FHO 3LQV 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6Y53 6Y5Q 7ABG 7ABH 7ABI 7DVQ 7Q4O 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	4UG0 4V6X 5A8L 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		U2-type Prespliceosome Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Gene Expression Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Protein Heterodimerization Activity Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Neuregulin Receptor Activity Spliceosomal Complex Assembly Poly-pyrimidine Tract Binding U11/U12 SnRNP Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Spontaneous Synaptic Transmission Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Developmental Maturation Axon Midline Choice Point Recognition Intracellular Signaling Cassette NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Lipid Biosynthetic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Signal Transduction Low-density Lipoprotein Particle Receptor Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Phospholipid Efflux Regulation Of Wnt Signaling Pathway Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cell Population Proliferation Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Signaling Negative Regulation Of Developmental Process Antioxidant Activity Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Protein Metabolic Process
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