PDHA2 and PDHB

Number of citations: 49 (PubMedID 26344197)
Data Source: BioGRID (biochemical), HPRD (in vivo)

		PDHA2	PDHB
Name		pyruvate dehydrogenase E1 subunit alpha 2	pyruvate dehydrogenase E1 subunit beta
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Purine-containing Compound Biosynthetic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR
Drugs		NADH	Pyruvic acid NADH
Diseases		None	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Metabolite levels ( 23823483 ) Triacylglyceride levels ( 31551469 )	Apolipoprotein B levels ( 32203549 ) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107 ) IgG levels ( 28628107 ) LDL cholesterol levels ( 32203549 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 26502338 28714469 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) vWF levels ( 30586737 )
Novel Interactors		None recorded	1 novel interactors: ATXN7
Interacting Genes		2 interacting genes: MEOX2 PDHB	18 interacting genes: ADORA2A AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RBM11 RCC1 TRIM63 TSC22D1
Entrez ID		5161	5162
HPRD ID		01531	01530
Ensembl ID		ENSG00000163114	ENSG00000168291
Uniprot IDs		P29803	A0A384MDR8 P11177
PDB IDs		Not available	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
GO Terms Enriched among Interactors		Somite Specification Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase (acetyl-transferring) Activity Segment Specification Somite Development Acetyl-CoA Biosynthetic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Regulation Of Cell Migration Involved In Sprouting Angiogenesis Limb Development Negative Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Pattern Specification Skeletal Muscle Tissue Development Pyruvate Metabolic Process Negative Regulation Of Endothelial Cell Migration	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Acetyl-CoA Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Protein-containing Complex Binding Pyruvate Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Migration Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Positive Regulation Of Amino Acid Transport Cell Migration Involved In Sprouting Angiogenesis Glucose Metabolic Process Cellular Response To Low-density Lipoprotein Particle Stimulus Tricarboxylic Acid Cycle Amide Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Regulation Of Fibroblast Migration Carboxylic Acid Metabolic Process TRNA Methylation Organic Acid Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Blood Vessel Endothelial Cell Migration Regulation Of TRNA Methylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition High-affinity IgE Receptor Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Myoblast Fate Specification Integrin Alpha7-beta1 Complex Cellular Defense Response Protein Kinase Binding Monocarboxylic Acid Metabolic Process Excitatory Postsynaptic Potential Cellular Response To Amino Acid Starvation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Localization To Lysosome PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Type I Hypersensitivity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity