PIGT and GPAA1

Number of citations of the paper that reports this interaction (PubMedID 11483512)
42

Data Source:
HPRD (in vitro, in vivo)

		PIGT	GPAA1
Description		phosphatidylinositol glycan anchor biosynthesis class T	glycosylphosphatidylinositol anchor attachment 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle GPI-anchor Transamidase Complex	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex
	Molecular Function	Protein Binding GPI Anchor Binding	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding
	Biological Process	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein Neuron Differentiation Neuron Apoptotic Process GPI Anchored Protein Biosynthesis	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Attachment of GPI anchor to uPAR	Attachment of GPI anchor to uPAR
Drugs
Diseases
GWAS		Malaria ( 31844061)	Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944)
Interacting Genes		3 interacting genes: GPAA1 PIGK UPF3A	10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		51604	8733
HPRD ID		15136	04334
Ensembl ID		ENSG00000124155	ENSG00000197858
Uniprot IDs		Q969N2	O43292
PDB IDs		7W72 7WLD 8IMX 8IMY	7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Protein Maturation Glycerolipid Metabolic Process Phospholipid Metabolic Process Protein Retention In ER Lumen Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maintenance Of Protein Localization In Endoplasmic Reticulum Carbohydrate Derivative Biosynthetic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Lipid Biosynthetic Process Organophosphate Biosynthetic Process Exon-exon Junction Complex Telomeric DNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Carbohydrate Derivative Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maintenance Of Protein Localization In Organelle Positive Regulation Of RNA Splicing Organophosphate Metabolic Process Maintenance Of Protein Location In Cell Maintenance Of Protein Location Endoplasmic Reticulum Membrane Lipid Metabolic Process Maintenance Of Location In Cell Negative Regulation Of MRNA Catabolic Process Maintenance Of Location	GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process
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