PDE8A and SEC11A

Data Source: HiPPIP (Novel)

		PDE8A	SEC11A
Name		phosphodiesterase 8A	SEC11 homolog A, signal peptidase complex subunit
Structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Kinase Binding Protein Kinase Activator Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	CAMP Catabolic Process Regulation Of DNA-templated Transcription Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of CAMP/PKA Signal Transduction	Signal Peptide Processing Proteolysis Response To Virus
Pathways		G alpha (s) signalling events	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs		Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil	None
GWAS		Bulimia nervosa ( 23568457 ) Central corneal thickness ( 20719862 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Medication use (diuretics) ( 31015401 ) Neurofibrillary tangles ( 31497858 ) Systolic blood pressure ( 30224653 30578418 ) Testicular germ cell tumor ( 28604728 ) Waist circumference adjusted for body mass index ( 34021172 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Hip circumference adjusted for BMI ( 34021172 ) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317 ) Schizophrenia ( 29483656 )
Novel Interactors		1 novel interactors: SEC11A	10 novel interactors: AGBL1 CCL3 CCNDBP1 CEP76 KLHL25 LINC00052 OAZ2 PDE8A PDIA3 RAB27B
Interacting Genes		None recorded	5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		5151	23478
HPRD ID		09114	07503
Ensembl ID		ENSG00000073417	ENSG00000140612
Uniprot IDs		O60658	H0YKT4 P67812
PDB IDs		3ECM 3ECN 7CWA 7CWF 7CWG 7VSL 7VTV 7VTW 7VTX	7P2P
GO Terms Enriched among Interactors		Signal Peptidase Complex Signal Peptide Processing	None