PDE8A

Name	phosphodiesterase 8A
Structure
Novel Interactors	1 novel interactors: SEC11A
Interactors	None recorded
GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Kinase Binding Protein Kinase Activator Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process Regulation Of DNA-templated Transcription Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways	G alpha (s) signalling events
Drugs	Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil
GWAS	Bulimia nervosa ( 23568457 ) Central corneal thickness ( 20719862 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Medication use (diuretics) ( 31015401 ) Neurofibrillary tangles ( 31497858 ) Systolic blood pressure ( 30224653 30578418 ) Testicular germ cell tumor ( 28604728 ) Waist circumference adjusted for body mass index ( 34021172 )
Entrez ID	5151
HPRD ID	09114
Ensembl ID	ENSG00000073417
Uniprot IDs	O60658
PDB IDs	3ECM 3ECN 7CWA 7CWF 7CWG 7VSL 7VTV 7VTW 7VTX
GO Terms Enriched among Interactors ?	Signal Peptidase Complex Signal Peptide Processing