SEC11A and PDE8A

Data Source: HiPPIP (Novel)

		SEC11A	PDE8A
Name		SEC11 homolog A, signal peptidase complex subunit	phosphodiesterase 8A
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane	Cytosol Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Kinase Binding Protein Kinase Activator Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Peptide Processing Proteolysis Response To Virus	CAMP Catabolic Process Regulation Of DNA-templated Transcription Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins	G alpha (s) signalling events
Drugs		None	Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Hip circumference adjusted for BMI ( 34021172 ) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317 ) Schizophrenia ( 29483656 )	Bulimia nervosa ( 23568457 ) Central corneal thickness ( 20719862 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Medication use (diuretics) ( 31015401 ) Neurofibrillary tangles ( 31497858 ) Systolic blood pressure ( 30224653 30578418 ) Testicular germ cell tumor ( 28604728 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		10 novel interactors: AGBL1 CCL3 CCNDBP1 CEP76 KLHL25 LINC00052 OAZ2 PDE8A PDIA3 RAB27B	1 novel interactors: SEC11A
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6	None recorded
Entrez ID		23478	5151
HPRD ID		07503	09114
Ensembl ID		ENSG00000140612	ENSG00000073417
Uniprot IDs		H0YKT4 P67812	O60658
PDB IDs		7P2P	3ECM 3ECN 7CWA 7CWF 7CWG 7VSL 7VTV 7VTW 7VTX
GO Terms Enriched among Interactors		None	Signal Peptidase Complex Signal Peptide Processing