SEC11A and AGBL1

		SEC11A	AGBL1
Description		SEC11 homolog A, signal peptidase complex subunit	AGBL carboxypeptidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane	Cytoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Tubulin Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Signal Peptide Processing Proteolysis Response To Virus	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins	Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Activated partial thromboplastin time ( 22703881) Acute lymphoblastic leukemia ( 33891562) Acute lymphoblastic leukemia (adult) ( 33891562) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212) Triiodothyronine levels ( 30843173) Venous thromboembolism ( 33592630)
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		23478	123624
HPRD ID		07503	07115
Ensembl ID		ENSG00000140612	ENSG00000273540
Uniprot IDs		H0YKT4 P67812	A0A1B0GVQ2 Q96MI9
PDB IDs		7P2P
Enriched GO Terms of Interacting Partners?			PH Domain Binding Signal Peptide Processing Signal Peptidase Complex Insulin Receptor Substrate Binding
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