SEC11A and KLHL25

		SEC11A	KLHL25
Description		SEC11 homolog A, signal peptidase complex subunit	kelch like family member 25
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane	Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Signal Peptide Processing Proteolysis Response To Virus	Regulation Of Translation Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Protein Ubiquitination Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Oxidation Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel) ( 24025145) Aging traits ( 17903295) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Idiopathic pulmonary fibrosis ( 29066090) Offspring birth weight ( 31043758) Psychosis (methamphetamine induced) ( 23594818) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6	1 interacting genes: ACLY
Entrez ID		23478	64410
HPRD ID		07503	07780
Ensembl ID		ENSG00000140612	ENSG00000183655
Uniprot IDs		H0YKT4 P67812	Q9H0H3
PDB IDs		7P2P
Enriched GO Terms of Interacting Partners?			Citrate Metabolic Process ATP Citrate Synthase Activity Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Signal Peptidase Complex Oxaloacetate Metabolic Process Negative Regulation Of Ferroptosis Coenzyme A Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Ferroptosis Signal Peptide Processing Tricarboxylic Acid Metabolic Process Cholesterol Biosynthetic Process Acetyl-CoA Metabolic Process Sterol Biosynthetic Process Azurophil Granule Lumen Acyl-CoA Metabolic Process Steroid Biosynthetic Process Dicarboxylic Acid Metabolic Process Sulfur Compound Biosynthetic Process
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