UFC1 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UFC1	GEMIN4
Description		ubiquitin-fold modifier conjugating enzyme 1	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies
	Molecular Function	Protein Binding UFM1 Conjugating Enzyme Activity UFM1 Transferase Activity	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Brain Development Regulation Of Type II Interferon Production Response To Endoplasmic Reticulum Stress Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing
Pathways			snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: ANKRD11 GEMIN4 NTAQ1 UFL1	57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		51506	50628
HPRD ID		15643	07370
Ensembl ID		ENSG00000143222	ENSG00000179409
Uniprot IDs		Q9Y3C8	I3L2C7 P57678 Q8WUM5 Q9HC39
PDB IDs		2K07 2Z6O 2Z6P 3EVX 7NVJ 7NVK 7NW1 7OVC 8BZR 8C0D
Enriched GO Terms of Interacting Partners?		UFM1 Transferase Activity UFM1 Ligase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Positive Regulation Of Reticulophagy Protein K69-linked Ufmylation Regulation Of Reticulophagy	SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process
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