UFC1 and UFL1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		UFC1	UFL1
Description		ubiquitin-fold modifier conjugating enzyme 1	UFM1 specific ligase 1
Image
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection
	Molecular Function	Protein Binding UFM1 Conjugating Enzyme Activity UFM1 Transferase Activity	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity
	Biological Process	Brain Development Regulation Of Type II Interferon Production Response To Endoplasmic Reticulum Stress Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Diastolic blood pressure ( 27841878) Headache ( 29397368) Language functional connectivity ( 34929384) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)
Interacting Genes		4 interacting genes: ANKRD11 GEMIN4 NTAQ1 UFL1	17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219
Entrez ID		51506	23376
HPRD ID		15643	11109
Ensembl ID		ENSG00000143222	ENSG00000014123
Uniprot IDs		Q9Y3C8	O94874
PDB IDs		2K07 2Z6O 2Z6P 3EVX 7NVJ 7NVK 7NW1 7OVC 8BZR 8C0D	8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD
Enriched GO Terms of Interacting Partners?		UFM1 Transferase Activity UFM1 Ligase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Positive Regulation Of Reticulophagy Protein K69-linked Ufmylation Regulation Of Reticulophagy
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