AMY2A

Description		amylase alpha 2A
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Catalytic Activity Alpha-amylase Activity Calcium Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Chloride Ion Binding Cation Binding Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Carbohydrate Catabolic Process Polysaccharide Digestion
Pathways		Digestion of dietary carbohydrate Developmental Lineage of Pancreatic Acinar Cells
Drugs		Acarbose Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam N-[4-hydroxymethyl-cyclohexan-6-yl-1,2,3-triol]-4,6-dideoxy-4-aminoglucopyranoside Beta-D-Glucose 4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose Pidolic acid 5-Hydroxymethyl-Chonduritol 4,6-dideoxy-4-amino-alpha-D-glucose 6)-Alpha-L-Threo-Hexopyranose alpha-D-quinovopyranose Acarbose Derived Hexasaccharide 4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose 4)HEXOPYRANOSE
Diseases
GWAS
Interacting Genes		3 interacting genes: GP2 IGF1R TRIAP1
Entrez ID		279
HPRD ID		00094
Ensembl ID		ENSG00000243480
Uniprot IDs		P04746 Q53F26
PDB IDs		1B2Y 1BSI 1CPU 1HNY 1KB3 1KBB 1KBK 1KGU 1KGW 1KGX 1U2Y 1U30 1U33 1XCW 1XCX 1XD0 1XD1 1XGZ 1XH0 1XH1 1XH2 2CPU 2QMK 2QV4 3BAI 3BAJ 3BAK 3BAW 3BAX 3BAY 3CPU 3IJ7 3IJ8 3IJ9 3OLD 3OLE 3OLG 3OLI 4GQQ 4GQR 4W93 4X9Y 5E0F 5EMY 5KEZ 5TD4 5U3A 5VA9 6OBX 6OCN 6Z8L
Enriched GO Terms of Interacting Partners?		Transcytosis Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin Receptor Activity Insulin Binding Phosphatidic Acid Transfer Activity Zymogen Granule Membrane Phosphatidylinositol 3-kinase Binding Peptidyl-tyrosine Autophosphorylation Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Dendritic Spine Maintenance Insulin Receptor Substrate Binding Protein Transporter Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic G1/S Transition Checkpoint Signaling Mitotic G1 DNA Damage Checkpoint Signaling Positive Regulation Of Phospholipid Transport Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Insulin Receptor Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Amyloid-beta Clearance
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