SPOUT1 and MIR34B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SPOUT1	MIR34B
Description		SPOUT domain containing methyltransferase 1	microRNA 34b
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Spindle Pole Centrosome Mitotic Spindle
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity Transferase Activity MiRNA Binding RRNA (uridine-N3-)-methyltransferase Activity S-adenosyl-L-methionine Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RRNA Processing Post-transcriptional Regulation Of Gene Expression Methylation MiRNA Processing Cell Division Maintenance Of Centrosome Location RRNA Base Methylation	Negative Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756)
Interacting Genes		52 interacting genes: CSNK2B INCA1 MIR1-1 MIR106A MIR106B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR34A MIR34B MIR429 MIR7-1 MIR9-1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PLK1	109 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2 ATXN2L C1QBP CDC5L CELF1 CELF2 CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MTERF3 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PIP5K1A PLOD1 PTBP1 PTBP3 PTCD3 PUF60 PURA PURB QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBM45 RBM4B RTCA RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM56 U2SURP UPF1 USP36 UTP20 WDR33 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		51490	407041
HPRD ID		12935
Ensembl ID		ENSG00000198917	ENSG00000207811
Uniprot IDs		Q5T280
PDB IDs		4RG1 8QSU 8QSV 8QSW
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Angiogenesis Regulation Of RNA Stability Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Regulation Of Cell Migration Regulation Of Vasculature Development Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Regulation Of Locomotion Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of MRNA Metabolic Process Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization TRNA Aminoacylation MRNA Stabilization Regulation Of Primary Metabolic Process Regulation Of RNA Stability RNA Transport Regulation Of MRNA Stability U2 SnRNP Positive Regulation Of Gene Expression Regulation Of Metabolic Process Ligase Activity Protein-RNA Complex Assembly
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