SPOUT1

Description		SPOUT domain containing methyltransferase 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Spindle Pole Centrosome Mitotic Spindle
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity Transferase Activity MiRNA Binding RRNA (uridine-N3-)-methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	RRNA Processing Post-transcriptional Regulation Of Gene Expression Methylation MiRNA Processing Cell Division Maintenance Of Centrosome Location RRNA Base Methylation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		52 interacting genes: CSNK2B INCA1 MIR1-1 MIR106A MIR106B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR34A MIR34B MIR429 MIR7-1 MIR9-1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PLK1
Entrez ID		51490
HPRD ID		12935
Ensembl ID		ENSG00000198917
Uniprot IDs		Q5T280
PDB IDs		4RG1 8QSU 8QSV 8QSW
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Angiogenesis Regulation Of RNA Stability Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Regulation Of Cell Migration Regulation Of Vasculature Development Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Regulation Of Locomotion Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration
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