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ANAPC5 and FBXO5
Number of citations of the paper that reports this interaction (PMID
16921029
)
58
Data Source:
BioGRID
(affinity chromatography technology, pull down)
ANAPC5
FBXO5
Gene Name
anaphase promoting complex subunit 5
F-box protein 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Molecular Function
Protein Phosphatase Binding
Protein Binding
Protein Kinase Binding
Metal Ion Binding
Biological Process
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Oocyte Maturation
Spindle Assembly Involved In Female Meiosis I
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Vesicle Organization
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Meiotic Nuclear Division
Microtubule Polymerization
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Inhibition Of APC-Cdc20 Complex Activity
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
E2F mediated regulation of DNA replication
G1/S Transition
G1/S-Specific Transcription
SCF-beta-TrCP mediated degradation of Emi1
Regulation of mitotic cell cycle
Mitotic Metaphase/Anaphase Transition
Phosphorylation of Emi1
Regulation of APC/C activators between G1/S and early anaphase
Mitotic G1-G1/S phases
M Phase
Mitotic Metaphase and Anaphase
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
14 interactors:
ANAPC2
ANAPC4
BACH1
CDC20
CREBBP
FBXO5
FZR1
MAPK6
PABPC1
SMURF1
SMURF2
TGFBR1
UBE2S
ZBTB16
16 interactors:
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
BTRC
CDC16
CDC20
CDC23
CDC27
CDK1
EVI5
FZR1
SKP1
TPM3
Entrez ID
51433
26271
HPRD ID
10453
09348
Ensembl ID
ENSG00000089053
ENSG00000112029
Uniprot IDs
B4DFK4
F5H0F9
Q9UJX4
Q9UKT4
PDB IDs
2M6N
Enriched GO Terms of Interacting Partners
?
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Modification-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Cellular Macromolecule Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Protein Ubiquitination
Cellular Protein Metabolic Process
Activation Of Anaphase-promoting Complex Activity
Positive Regulation Of Cellular Metabolic Process
Cell Cycle
Positive Regulation Of Transferase Activity
Mitotic Nuclear Division
Regulation Of Mitotic Sister Chromatid Separation
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Cell Cycle Process
Protein Polyubiquitination
Mitotic Cell Cycle Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Protein Metabolic Process
Cellular Protein Modification Process
Mitotic Cell Cycle
Negative Regulation Of Cellular Protein Catabolic Process
Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Ubiquitin-protein Transferase Activity
Spindle Assembly Checkpoint
Positive Regulation Of Proteolysis
Mitotic Spindle Checkpoint
Negative Regulation Of Chromosome Segregation
Spindle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Cell Division
Cell Cycle Checkpoint
Regulation Of Chromosome Segregation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Positive Regulation Of Transferase Activity
Negative Regulation Of Chromosome Organization
Mitotic Cell Cycle Checkpoint
Protein Catabolic Process
Protein Polyubiquitination
Cell Division
Regulation Of Proteolysis
Mitotic Cell Cycle Process
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Nuclear Division
Negative Regulation Of Protein Catabolic Process
Tagcloud
?
atl
bortezomib
cdc37
cobalt
exhibiting
faf1
fas
folding
heme
hif
hmox
hspa1a
hspa1b
hspca
htlv
instead
lethal
leukaemia
mt
neoplasia
oligonucleotide
oxygenase
pharmacologically
protoporphyrin
regimens
stabilisation
stip1
tay
urgently
Tagcloud (Difference)
?
atl
bortezomib
cdc37
cobalt
exhibiting
faf1
fas
folding
heme
hif
hmox
hspa1a
hspa1b
hspca
htlv
instead
lethal
leukaemia
mt
neoplasia
oligonucleotide
oxygenase
pharmacologically
protoporphyrin
regimens
stabilisation
stip1
tay
urgently
Tagcloud (Intersection)
?