ANAPC5

Description		anaphase promoting complex subunit 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton
	Molecular Function	Protein Phosphatase Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: SBNO1
Interacting Genes		10 interacting genes: BACH1 CREBBP ID2 MAPK6 PABPC1 SMURF1 SMURF2 TGFBR1 UBE2S ZBTB16
Entrez ID		51433
HPRD ID		10453
Ensembl ID		ENSG00000089053
Uniprot IDs		F5H0F9 Q9UJX4
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		SMAD Binding Regulation Of Primary Metabolic Process Protein Modification Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway I-SMAD Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Embryonic Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Developmental Process Kidney Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Neuron Fate Commitment Transferase Activity Macromolecule Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Non-canonical Wnt Signaling Pathway Regulation Of Chondrocyte Differentiation Ubiquitin-protein Transferase Activity Embryonic Digit Morphogenesis Wnt Signaling Pathway Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Engulfment Of Target By Autophagosome Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytosol Positive Regulation Of Fat Cell Differentiation Negative Regulation Of BMP Signaling Pathway Regulation Of Cartilage Development Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Histone H3K27 Acetyltransferase Activity Septin Cytoskeleton Vascular Endothelial Cell Proliferation Epicardium Morphogenesis
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